Knockdown of TMEM189 mRNA by siRNA in A431 cells (Fig. Also with myc-tagged proteins, only transfection of TMEM189-6x myc resulted in the formation of alk-1′-enyl lipids (SI Appendix, Fig. Plasmalogen levels remained largely unchanged by replacement of one WT allele with the inactive tg (two-tailed P = 0.577 for males and 0.333 for females; n = 3 each), whereas homozygous animals with both alleles as tg had almost completely lost their plasmalogens (two-tailed P, WT/WT vs tg/tg = 0.0021 for males, <0.0001 for females, unpaired t test; n = 3 each) (Fig.

A substance may have its use restricted to certain articles or products and therefore not all the examples may apply to the specific substance. Notification à l’inventaire des classifications et des étiquetages, Avis du comité des produits biocides sur l’approbation de la substance active, Autorisation nationale et reconnaissance mutuelle, Produits chimiques soumis au règlement PIC, Valeurs limites d’exposition professionnelle, Comprendre la directive-cadre relative aux déchets, Planification et communication d’informations, Liste des substances soumises au règlement POP, Liste des substances dont l’inclusion sur la liste des POP est proposée, Projet de recommandation pour l’inclusion dans la liste d'autorisation et la consultation, Restrictions soumises actuellement à l’examen, Consultations relatives aux nouvelles preuves scientifiques, Appels actuels à commentaires et éléments de preuve, Consultations ciblant la classification et l’étiquetage harmonisés, Consultations relatives aux demandes du directeur exécutif de l’ECHA, État d’avancement de l’évaluation des dossiers, PACT - Outil de coordination des activités publiques, Évaluation des substances - plan d’action continu communautaire (CoRAP), Informations concernant les substances inscrites sur la liste des substances candidates contenues dans des articles, Substances soumises à restriction dans le cadre de REACH, Liste des substances faisant l’objet d’une autorisation, Liste des substances extrêmement préoccupantes candidates en vue d’une autorisation, Registre d’intentions de restriction jusqu’à l’issue du processus, Registre d’intentions d’identification en tant que SVHC jusqu’à l’issue du processus, Tableau d’entrées harmonisées disponible à l’annexe VI du CLP, Registre d’intentions de classification et d’étiquetage jusqu’à l’issue du processus, Liste des substances actives et fournisseurs, Produits chimiques soumis à un consentement préalable en connaissance de cause, Limites d’exposition professionnelle — Liste d’activités, Autorisation d’utilisation des substances extrêmement préoccupantes, Identification des substances extrêmement préoccupantes (MSC), Classification et étiquetage harmonisés (CER), Identifiez vos obligations en tant qu’entreprise, Comment améliorer votre dossier d’enregistrement, Comment présenter une demande d’autorisation, Comment soumettre des rapports d’utilisateurs en aval, Soumission de dossiers de classification et d’étiquetage (CLH), Documents relatifs aux scénarios d’émission, Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment, Guidance on the safe use of the substance, PACT - Public activities Co-ordination Tool, CAD - Chemical Agents Directive, Art. We thank Sanger Mouse Pipelines for providing mouse phenotyping data on the Tmem189tm1a(KOMP)Wtsi colony. The source of the information is mentioned in the introductory sentence of the hazard statements. If generated, an InChI string will also be generated and made available for searching.

Two regions containing the conserved histidines are shown. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Note that this list is not exhaustive. This substance is used in the following products: adhesives and sealants. This section is based on three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). If the substance is covered by more than one CLH entry (e.g. In that case, the ATP (Adaptation to Technical Progress) number is displayed.

(A) Amino acid sequence comparison of pfam10520 motif containing proteins.

Plasmalogen levels were strongly reduced in all organs of the mouse that we tested, indicating that no isoenzyme encoded by a gene different from Tmem189 is present in these tissues to carry out the PEDS reaction. De plus amples informations sur la pratique multilingue de l'ECHA sont disponibles. The enzymatic activity was found in the microsomal fraction of tissues or cells (21, 22), thus being membrane-bound and likely originating from the endoplasmic reticulum. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. If the substance was not covered by the EC Inventory, ECHA attributes a list number in the same format, starting with the numbers 6, 7, 8 or 9.

We then correlated for each of these genes, separately for human cell lines and for mouse tissues, the normalized mRNA sequencing counts with PEDS enzymatic activity that we had observed previously (22) (Fig. 4B), plasmalogens were also found to be strongly reduced in 12 other tissues of homozygous tg-carrying mice (SI Appendix, Fig. 215–540–4, is covered by three harmonisations: 005–011–00–4; 005–011–01–1 and 005–011–02–9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. The expression pattern showed localization in the endoplasmic reticulum by an overlay of the green fluorescence signal with ER Tracker Red (SI Appendix, Fig. Neural signatures of complex cognitive processing can occur in the absence of visual awareness, according to a case study of a person with distorted visual perception.
in case of consumer and professional uses). For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet. A mouse deficient in our gene of interest was available from the European Mutant Mouse Archive, and a systematic study of its phenotype had already been performed by the International Mouse Phenotyping Consortium, allowing us to interpret it on the basis of our biochemical findings regarding the role of the Tmem189 gene in encoding PEDS. PubChem Substance ID 24865868.

Murine Tmem189 cDNA was cloned into pEGF-N1 (Clontech), and the TMEM189-GFP fusion protein was expressed in HEK-293T cells. According to the annexes to the directive, storage areas and containers containing chemical substances or mixtures that are classified as hazardous according to the CLP Regulation (1272/2008/EC) must be marked and/or labeled.

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Molecular Formula.

Workplace Signage: Annexes I and III, Directive 92/58/EEC, last amended by Directive 2014/27/EU, 5 March 2014, EU. Substances for which an agreed set of classification and labelling data has been agreed at EU level by Member States.

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